1Several reviewers identify the Glycerin 22's full-length DNA Tuned nitrogen-infused super-critical foam midsole as its defining feature, noting it brings foam technology typically reserved for racing or workout shoes into a daily trainer.
The Glycerin 22 represents Brooks putting premium super-critical foam into an everyday trainer, which buyers should expect to feel noticeably different from traditional EVA-based daily shoes.
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Opinions (13)
The Run Testers mentions having tested the Glycerin 22 (referring to it as the Glycerin 22 when discussing the Glycerin line); he notes that the Glycerin line uses DNA Tuned foam, which he finds a little bit better than DNA Loft v3, though not night and day, and that you do get a bit more energy out of the DNA Tuned foam and it is cushy back.
Brooks Ghost 18 Review: A dependable daily trainer that lacks pizzazz7:37RadDadBodTV describes the Glycerin 22 as the second shoe to use DNA Tuned foam (after the Glycerin Max).
Brooks Glycerin 23 - Big Midsole Changes! Watch sourceRoadTrailRun finds the Brooks Glycerin 22 has a DNA tuned foam midsole which is a dual foam with smaller cells in the front for more response and bigger cells in the back for more cushion.
Brooks Glycerin Line Comparison Review: New Glycerin Flex and Glycerin Max 2, Glycerin 23Watch sourceMarathon Handbook observes that Brooks completely revamped the Glycerin 22's midsole compared to prior versions, making it entirely super-critical DNA Tune foam with dual-cell technology.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39Marathon Handbook observes that the Glycerin 22 uses DNA Tune foam, the same type of light, responsive foam Brooks uses in many of their workout shoes.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39Marathon Handbook states the Brooks Glycerin 22's entire midsole is made out of a 'special light and responsive kind of foam' called super critical foam.
Puma Velocity Nitro 4 | Was this NECESSARY?Watch sourcekofuzi describes the Brooks Glycerin 22 as having DNA Tuned dual density midsole foam.
Brooks Hyperion Elite 56:50Marathon Handbook observes that the magic of the Glycerin 22 is in the midsole, made of a super-critical foam that is a lot more comfy and a lot more responsive than the foam from past Glycerin versions.
Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook states that the whole midsole is made of what Brooks calls nitrogen-infused DNA Tuned foam.
Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook states that this version of the Glycerin 22 has dual-cell technology — tiny pods in the midsole that help absorb shock in the heel and propel forward at the toe.
Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook observes that the Glycerin 22 has DNA Tuned foam — the kind of super-critical foam you would find in a super shoe, not in an easy running shoe.
Brooks Glycerin 22: the most ADVANCED easy running shoe?3:54Marathon Handbook notes the Brooks Glycerin 22's midsole is made of nitrogen-infused DNA Tuned foam, a super-critical foam Brooks uses in workout shoes like the Glycerin Max and the Hyperion Max.
[OLD] Review l The Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook observes the Brooks Glycerin 22 has dual-cell technology with tiny pods in the midsole that absorb shock in the heel and propel forward at the toe.
[OLD] Review l The Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch source
2One reviewer (Marathon Handbook) describes the Glycerin 22 as a dramatic improvement over the Glycerin 21, calling it a fundamentally different and far better shoe.
If you were underwhelmed by the Glycerin 21, the 22 is widely regarded as a major leap forward rather than an incremental update.
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Opinions (9)
Marathon Handbook states that the Brooks Glycerin 22 was a lot different from the Brooks Glycerin 21, noting that such shoe-to-shoe evolutions do happen but are not the norm.
The Best Running Shoe to Buy at EVERY Price Point l $150 to $300+13:34Marathon Handbook ranks the Brooks Glycerin 23 as number three, noting there is almost no difference between the Glycerin 22 and 23; the big change came between the 21 and 22 when Brooks introduced its own nitrogen-infused foam.
Top 5 Daily Trainers 2026 so far3:28Marathon Handbook finds the Glycerin 22 much more responsive and alive compared to the Glycerin 21, and describes the one-year difference as 'incredible'.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39
3Several reviewers praise the Glycerin 22's comfort, with some calling it unmatched and noting it provides a plush, cradling feel that is easy on the joints.
Comfort is a standout strength of the Glycerin 22, making it a strong choice for runners who prioritize a plush, forgiving ride on easy and recovery days.
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Opinions (8)
Marathon Handbook states that the Glycerin 22's comfort is 'unmatched'.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more7:17kofuzi finds the Glycerin 22 to be a very comfortable shoe.
Brooks Hyperion Elite 56:50Marathon Handbook finds the Glycerin 22 comfortable to put on — comfortable to land on and a nice cradle for the entire foot — and says 'I don't think you can get a blister in these shoes, I don't think it's possible.'
Brooks Glycerin 22: the most ADVANCED easy running shoe?3:54Marathon Handbook finds the Brooks Glycerin 22 provides a comfortable cradle for the entire foot and believes it is impossible to get a blister in them.
4Opinions differ on the Glycerin 22's responsiveness and energy return, with some reviewers finding it lively and bouncy for an easy shoe while others found the midsole flat and lacking pop, particularly in the forefoot.
The Glycerin 22's energy return is divisive — runners who want a lively, poppy feel should try before buying, as some found the forefoot dead despite the premium foam.
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Opinions (9)
Marathon Handbook finds the Glycerin 22 much more responsive and alive compared to the Glycerin 21, and describes the one-year difference as 'incredible'.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39Marathon Handbook finds the Glycerin 22 way more responsive than a typical easy running shoe.
The Brooks Glycerin 22 is the BEST easy running shoe of 2025 so far🔥Watch sourceMarathon Handbook finds the Glycerin 22 has a good amount of bounce and responsiveness, not dead like easy running shoes, but also not a workout shoe that springs you onto your toes (which you don't want on easy days).
Brooks Glycerin 22: the most ADVANCED easy running shoe?3:54
5Reviewers are divided on how to position the Glycerin 22: several (RoadTrailRun, kofuzi, The Run Testers) frame it primarily as an easy, recovery, or long-run shoe, while Marathon Handbook describes it as versatile enough for workouts and faster paces as well.
Most reviewers see the Glycerin 22 as a dedicated easy-day shoe rather than a do-everything trainer, though a minority found it capable enough for workouts and fartlek.
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Opinions (7)
RoadTrailRun finds the Brooks Glycerin 22 a good bet for slow, easy runs at moderate paces due to its inherent stability.
Brooks Glycerin Line Comparison Review: New Glycerin Flex and Glycerin Max 2, Glycerin 234:46kofuzi characterizes the Glycerin 22 as a shoe you look to for comfort, not necessarily for pure performance.
Brooks Hyperion Elite 56:50The Run Testers says the Glycerin 22 does a good job of taming the road without needing more foam under foot, and he personally prefers a lower-profile, more directional feel.
Brooks Ghost Max 3 Review: Four runners deliver their verdict on Brooks' big cushioned daily20:12
6One reviewer classifies the Glycerin 22 in the "firm and supportive" category among max-cushion shoes, ranking it 25th out of roughly 30 from softest to firmest.
Despite its plush reputation among other reviewers, this systematic ranking suggests the Glycerin 22 is on the firmer end of the max-cushion spectrum, which may appeal to runners who want stability over sink-in softness.
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Opinions (5)
Yowana classifies the Brooks Glycerin 22 in the 'firm and supportive' category of max cushion shoes.
I Ranked EVERY Max Cushion Shoe From SOFTEST TO FIRMEST14:22Yowana lists the Brooks Glycerin 22 as number 25 (out of ~30) in the softest-to-firmest ranking of max cushion shoes, within the 'firm and supportive' group.
I Ranked EVERY Max Cushion Shoe From SOFTEST TO FIRMEST24:25- Yowana
The full firm-and-supportive list from softest to firmest includes: Cloud Monster Hyper, Supernova Prima 2, Vomero 18, Puma MagX, Hoka Bondi 9, Saucony Triumph 23, Brooks Ghost Max 3, Brooks Glycerin 22, Hoka Skyflow, Under Armour Infinite Mega, and ASICS Super Blast 2.
I Ranked EVERY Max Cushion Shoe From SOFTEST TO FIRMEST24:25
7One reviewer (Marathon Handbook) reports mixed durability experiences with the Glycerin 22 across multiple videos: several hundred kilometers of comfortable use, roughly 700 km before the ride felt flat, and an assessment that durability is good but has been outlasted by contemporaries.
Durability is decent but not class-leading; runners who prioritize maximum lifespan may find better options, though the Glycerin 22 should still deliver several hundred kilometers of comfortable running.
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Opinions (4)
Marathon Handbook has worn the Glycerin 22 from the last two years extensively and it lasted several hundreds of kilometers.
Brooks Glycerin 23 vs Glycerin Flex: OUR 100% HONEST Comparison3:26Marathon Handbook reports putting approximately 700 comfortable, bouncy kilometers on the Glycerin 22 before the ride started to feel 'a little bit flat', and speculates it could possibly extend to 800 km.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39Marathon Handbook finds that the Glycerin 22's durability is 'really good' for an easy running shoe, but has been outlasted by some of its contemporaries.
The Best Daily Running Shoes 2025 | Nike, ASICS, Brooks, and more3:39
8Multiple reviewers note the Glycerin 22 is a heavier, taller shoe with a 10 mm drop and a 38 mm stack height, describing it as bigger and chunkier than its predecessor.
The Glycerin 22 is a substantial, high-stack shoe with a traditional 10 mm drop — runners who prefer lightweight, low-profile, or ground-feel shoes should look elsewhere.
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Opinions (9)
RadDadBodTV states the Glycerin 22 had a 10 mm drop.
Brooks Glycerin 23 - Big Midsole Changes! Watch sourceRoadTrailRun states the Brooks Glycerin 22 has a 10 mm drop.
Brooks Glycerin Line Comparison Review: New Glycerin Flex and Glycerin Max 2, Glycerin 23Watch sourcekofuzi states the Glycerin 22 is a bigger shoe and a little bit more heavy.
Brooks Hyperion Elite 56:50Marathon Handbook measured that the Brooks Glycerin 22 is half an ounce heavier than the Glycerin 21 and also 10 mm taller (stack height).
9One reviewer (Marathon Handbook) compares the Glycerin 22 to the Glycerin Max, finding them similar in weight and midsole but noting the 22 lacks the Max's rocker-forward profile and is less likely to push the runner onto their toes.
The Glycerin 22 offers a Max-like foam experience in a less aggressive, less rockered package — buyers who want the Max's cushioning without its forward-rolling geometry may prefer the 22.
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Opinions (8)
Marathon Handbook observes that the Glycerin 22 and the Brooks Glycerin Max (their super trainer from fall 2024) have almost the same weight and midsole.
Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook says they were excited to try the Glycerin 22 as an easy running version of the Glycerin Max.
Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch sourceMarathon Handbook confirms after runs that the Glycerin 22 is nothing like the Glycerin 21 and a lot more like the Glycerin Max.
Brooks Glycerin 22: the most ADVANCED easy running shoe?3:54
10One reviewer found the Saucony Ride 18 superior to the Glycerin 22, describing it as nicer to run in with a livelier midsole and better heel-to-toe transition, while also being cheaper.
The Glycerin 22 faces strong value competition from cheaper daily trainers; budget-conscious buyers may want to compare against the Saucony Ride 18.
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Opinions (4)
The Run Testers compares the Saucony Ride 18 to the Brooks Glycerin 22 and finds the Ride 18 is the superior shoe.
Saucony Ride 18 Full Review | A fantastic daily workhorse with plenty of comfort9:26The Run Testers finds the Brooks Glycerin 22 is more expensive than the Saucony Ride 18.
Saucony Ride 18 Full Review | A fantastic daily workhorse with plenty of comfort9:26The Run Testers finds the Saucony Ride 18 is a bit nicer to run in than the Brooks Glycerin 22, with a midsole that is a bit more lively and enjoyable, and a heel-to-toe transition that is a bit better.
Saucony Ride 18 Full Review | A fantastic daily workhorse with plenty of comfort9:26
11One reviewer notes the Glycerin 22 is a bit more expensive than an average running shoe but considers the higher price warranted by its premium materials.
The Glycerin 22's price is above average for a daily trainer, but at least one reviewer felt the super-critical foam justifies the premium.
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Opinions (2)
Marathon Handbook observes that the Glycerin 22 is a little bit more pricey than an average shoe, but considers that warranted — better materials, higher price, you get what you pay for.
Brooks Glycerin 22: the most ADVANCED easy running shoe?3:54Marathon Handbook observes the Brooks Glycerin 22 is a bit more pricey than average running shoes, but considers the higher price warranted by better materials.
[OLD] Review l The Brooks Glycerin 22: the most ADVANCED easy running shoe?Watch source